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Abstract:
OBJECTIVE:To investigate the association between neurocognitive impairment, neuroimaging and systemic inflammation in perinatally-infected adolescents living with HIV (PHIV) on ART. Systemic inflammation may be one mechanism driving neurocognitive impairment despite ART, but this has not been investigated in adolescence when the brain is undergoing rapid development. SETTING:Cape Town, South Africa METHODS:: Baseline data were drawn from the Cape Town Adolescent Antiretroviral Cohort (CTAAC). PHIV on ART >6 months completed a comprehensive neurocognitive test battery. Diffusion tensor imaging and structural brain magnetic resonance imaging (MRI) was done to determine whole brain fractional anisotropy (FA), mean diffusivity (MD), grey and white matter volumes and cortical thickness. We examined how neurocognitive and neurostructural measures were associated with a concurrently measured marker of systemic inflammation, high-sensitive CRP (hs-CRP). RESULTS:168 PHIV ages 9-12 years (mean CD4 980 cells/µL; 85.3% VL<50 copies/mL) and 43 controls were included in the analysis. PHIV had similar hs-CRP (p=.17) to controls, after participants with hs-CRP >10 were excluded from the analysis. 48% of the PHIV in this analysis have a neurocognitive disorder. Whole brain grey (p=.049) and white matter volumes (p=.044) were lowest in PHIV with a major neurocognitive disorder. Higher MD, was found in PHIV with a major neurocognitive disorder (p=.002). Among PHIV with a neurocognitive disorder, hs-CRP negatively correlated with general intelligence, visual spatial acuity and executive function (all p=<.05). Whole brain MD correlated with higher hs-CRP values (p=<.01) in PHIV. CONCLUSION:A marker of systemic inflammation was associated with both neurocognitive impairment and mean diffusivity increases in PHIV.
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最新影响因子:3.771 | 期刊ISSN:1525-4135 | CiteScore: |
出版周期:Monthly | 是否OA:YES | 出版年份:1999 |
期刊官方网址:http://journals.lww.com/jaids/pages/default.aspx
期刊投稿地址:http://journals.lww.com/jaids/Pages/informationforauthors.aspx
自引率:9.30% | 研究方向:医学-传染病学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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JAIDS: Journal of Acquired Immune Deficiency Syndromes seeks to end the HIV epidemic by presenting important new science across all disciplines that advance our understanding of the biology, treatment and prevention of HIV infection worldwide. JAIDS: Journal of Acquired Immune Deficiency Syndromes is the trusted, interdisciplinary resource for HIV- and AIDS-related information with a strong focus on basic and translational science, clinical science, and epidemiology and prevention. Co-edited by the foremost leaders in clinical virology, molecular biology, and epidemiology, JAIDS publishes vital information on the advances in diagnosis and treatment of HIV infections, as well as the latest research in the development of therapeutics and vaccine approaches. This ground-breaking journal brings together rigorously peer-reviewed articles, reviews of current research, results of clinical trials, and epidemiologic reports from around the world.
JAIDS:《获得性免疫缺陷综合征杂志》试图通过介绍跨所有学科的重要新科学来结束艾滋病毒的流行,从而增进我们对全球艾滋病毒感染的生物学、治疗和预防的理解。 JAIDS:《获得性免疫缺陷综合征杂志》是值得信赖的、跨学科的HIV和aids相关信息资源,重点关注基础和转化科学、临床科学、流行病学和预防。JAIDS由临床病毒学、分子生物学和流行病学领域的顶尖领导者联合编辑,出版关于HIV感染诊断和治疗进展的重要信息,以及在治疗学和疫苗方法开发方面的最新研究。这本开创性的杂志汇集了来自世界各地经过严格同行评审的文章、对当前研究的评审、临床试验结果和流行病学报告。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
IMMUNOLOGY (免疫学) 3区 INFECTIOUS DISEASES (传染病学) 2区 |
49/155 20/88 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
341 | 335 | 6 |
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文献(2015-2017)
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影响因子:5.576
ISSN:0885-3924
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影响因子:3.006
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研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
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研究方向:医学-医学:内科
影响因子:0.522
ISSN:1108-4189
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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