Cognition, structural brain changes and systemic inflammation in adolescents living with HIV on antiretroviral therapy.

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Abstract:

OBJECTIVE:To investigate the association between neurocognitive impairment, neuroimaging and systemic inflammation in perinatally-infected adolescents living with HIV (PHIV) on ART. Systemic inflammation may be one mechanism driving neurocognitive impairment despite ART, but this has not been investigated in adolescence when the brain is undergoing rapid development. SETTING:Cape Town, South Africa METHODS:: Baseline data were drawn from the Cape Town Adolescent Antiretroviral Cohort (CTAAC). PHIV on ART >6 months completed a comprehensive neurocognitive test battery. Diffusion tensor imaging and structural brain magnetic resonance imaging (MRI) was done to determine whole brain fractional anisotropy (FA), mean diffusivity (MD), grey and white matter volumes and cortical thickness. We examined how neurocognitive and neurostructural measures were associated with a concurrently measured marker of systemic inflammation, high-sensitive CRP (hs-CRP). RESULTS:168 PHIV ages 9-12 years (mean CD4 980 cells/µL; 85.3% VL<50 copies/mL) and 43 controls were included in the analysis. PHIV had similar hs-CRP (p=.17) to controls, after participants with hs-CRP >10 were excluded from the analysis. 48% of the PHIV in this analysis have a neurocognitive disorder. Whole brain grey (p=.049) and white matter volumes (p=.044) were lowest in PHIV with a major neurocognitive disorder. Higher MD, was found in PHIV with a major neurocognitive disorder (p=.002). Among PHIV with a neurocognitive disorder, hs-CRP negatively correlated with general intelligence, visual spatial acuity and executive function (all p=<.05). Whole brain MD correlated with higher hs-CRP values (p=<.01) in PHIV. CONCLUSION:A marker of systemic inflammation was associated with both neurocognitive impairment and mean diffusivity increases in PHIV.

接受抗逆转录病毒治疗的 HIV 感染者青少年的认知、脑结构变化和全身炎症。

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摘要:

目的: 探讨接受 ART 治疗的围生期感染 HIV (PHIV) 青少年患者神经认知障碍、神经影像学和全身炎症之间的关系。尽管有 ART,全身性炎症可能是驱动神经认知障碍的一种机制,但这在大脑快速发育的青春期还没有被研究。 地点: 南非开普敦方法:: 基线数据来自开普敦青少年抗逆转录病毒队列 (CTAAC)。ART> 6 个月的 PHIV 完成了全面的神经认知测试。进行弥散张量成像和结构性脑磁共振成像 (MRI),以确定全脑各向异性分数 (FA) 、平均扩散率 (MD) 、灰质和白质体积以及皮质厚度。我们检测了神经认知和神经结构指标如何与同时测定的系统性炎症标志物高敏 CRP (hs-CRP) 相关。 结果: 168 hiv 年龄 9-12 岁 (平均 CD4 980 细胞/µ l; 85.3% VL10 被排除在分析之外。本分析中 48% 的 PHIV 有神经认知障碍。PHIV 合并主要神经认知障碍者全脑灰质 (p =.049) 和白质体积 (p =.044) 最低。较高的 MD,发现 PHIV 伴主要神经认知障碍 (p =.002)。在患有神经认知障碍的 PHIV 患者中,hs-CRP 与一般智力、视空间视力和执行功能呈负相关 (均 p =

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JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

研究方向:医学-传染病学
IF:3.731
IF值的bai意思是影响因子。是汤森路透(duThomson Reuters)出品的期刊引证报告zhi(Journal Citation Reports,JCR)中的一项数据。 影响因子dao目前的计算方法是:IF=C/(M+N)。以2017年IF的计算为例,M为该期刊2015年发表的文章数量,N为该期刊2016年发表的文章数量,C为该期刊2015和2016年两年发表的文章在2017年这一年被引用的
出版周期: UNITED STATES
中科院分区:Q4 来稿接收率:约 % 审稿周期:一般,3-6周
9.30%
YES
1999
1525-4135
出版地区: CiteScore:
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JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 期刊简介

英文简介:

JAIDS: Journal of Acquired Immune Deficiency Syndromes​ seeks to end the HIV epidemic by presenting important new science across all disciplines that advance our understanding of the biology, treatment and prevention of HIV infection worldwide. JAIDS: Journal of Acquired Immune Deficiency Syndromes is the trusted, interdisciplinary resource for HIV- and AIDS-related information with a strong focus on basic and translational science, clinical science, and epidemiology and prevention. Co-edited by the foremost leaders in clinical virology, molecular biology, and epidemiology, JAIDS publishes vital information on the advances in diagnosis and treatment of HIV infections, as well as the latest research in the development of therapeutics and vaccine approaches. This ground-breaking journal brings together rigorously peer-reviewed articles, reviews of current research, results of clinical trials, and epidemiologic reports from around the world.

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中文简介

JAIDS:《获得性免疫缺陷综合征杂志》试图通过介绍跨所有学科的重要新科学来结束艾滋病毒的流行,从而增进我们对全球艾滋病毒感染的生物学、治疗和预防的理解。 JAIDS:《获得性免疫缺陷综合征杂志》是值得信赖的、跨学科的HIV和aids相关信息资源,重点关注基础和转化科学、临床科学、流行病学和预防。JAIDS由临床病毒学、分子生物学和流行病学领域的顶尖领导者联合编辑,出版关于HIV感染诊断和治疗进展的重要信息,以及在治疗学和疫苗方法开发方面的最新研究。这本开创性的杂志汇集了来自世界各地经过严格同行评审的文章、对当前研究的评审、临床试验结果和流行病学报告。

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JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES期刊中科院评价数据

最新中科院JCR分区

大类(学科) 小类(学科) 学科排名
医学 IMMUNOLOGY(免疫学) 3区
INFECTIOUS DISEASES(传染病) 2区
49/155
20/88

最新公布的期刊年发文量

年度总发文量 年度论文发表量 年度综述发表量
341 335 6

总被引频次: 14479

特征因子: 0.037150

近年影响因子趋势图

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES期刊CiteScore评价数据

最新CiteScoere值

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引文计数(2018)

文献(2015-2017)

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次引用

篇文献

文献总数(2014-2016):

被引比率: %

SJR:
SCLmago期刊等级衡量经过加权后的期刊受引用次数,引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP:
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
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CiteScore排名

序号 类别(学科) 排名 百分位

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