发表一篇学和医学成像类SCI论文
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Abstract:
PURPOSE:Little is known about the underlying physiology that contributes to Haemoglobin A1c (HbA1c) in the normal and pre-diabetic range. We determined the contribution of fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), insulin secretion, insulin sensitivity and endogenous glucose production to HbA1c levels in the normal and pre-diabetic range. METHODS:A total of 62 Danish men and women with normal or impaired glucose regulation were studied. HbA1c levels were measured and participants underwent an oral glucose tolerance test with measurements of FPG and 2hPG, an intravenous glucose tolerance test for determination of first-phase insulin release, and a hyperinsulinaemic euglycaemic clamp for estimation of peripheral and hepatic insulin sensitivity. Associations of HbA1c with the different measures of glucose metabolism were analysed by linear regression analysis. RESULTS:HbA1c levels ranged from 28 to 45 mmol/mol (4.7-6.3%) in the study population. 1 SD higher (log) FPG concentration (~1 mmol/L) was associated with 2 mmol/mol higher HbA1c concentration (P < 0.001). In comparison, 1 SD higher levels of (log) first-phase insulin secretion or (log) disposition index were associated with 1.5 mmol/mol lower HbA1c levels (P < 0.05). HbA1c was not associated with peripheral or hepatic insulin sensitivity, endogenous glucose production or 2hPG levels. CONCLUSION:HbA1c levels within the normal and pre-diabetic range seem to reflect decreased insulin secretion to a higher extent than insulin resistance. Therefore, early prevention strategies for high-risk individuals identified by HbA1c are not straightforward. More research on how to improve the health of beta cells either directly or indirectly in high-risk individuals is needed.
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最新影响因子:3.925 | 期刊ISSN:1355-008X | CiteScore:2.55 |
出版周期: | 是否OA:YES | 出版年份:1994 |
自引率:9.60% | 研究方向:ENDOCRINOLOGY & METABOLISM- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Well-established as a major journal in today's rapidly advancing experimental and clinical research, Endocrine should be your first choice for the rapid publication of full length articles devoted to the molecular, cellular, biochemical, and physiological aspects of endocrinology, including both clinical papers relating to significant endocrine phenomena that are appropriately controlled and methodological papers of special interest to workers in this area.
完善作为主要在当今迅速发展的实验和临床研究杂志,内分泌的快速出版应该是你首选完整文章致力于分子,细胞,生化,内分泌学和生理方面的,包括临床论文重要内分泌相关现象,适当控制和方法论的论文工作者在这一领域的特殊利益。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 3区 |
62/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
303 | 272 | 31 |
引文计数(2018)
文献(2015-2017)
2668次引用
1047篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#77/209
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Endocrinology
|
#54/119
点击查看排名表
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审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:生物化学与分子生物学
接受率: 一般容易(75%命中)
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研究方向:垂体 甲状腺
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:医药科学 内分泌系统
审稿时间: 1个月内
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研究方向:甲状腺超声诊断 甲状腺消融 腹部、肝移植超声
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接受率: 一般容易(75%命中)
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研究方向:内分泌 代谢
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研究方向:内分泌 糖尿病
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影响因子:43.474
ISSN:1074-7613
研究方向:医学-免疫学
影响因子:2.957
ISSN:0891-6934
研究方向:医学-免疫学
影响因子:3.152
ISSN:0171-2985
研究方向:医学-免疫学
影响因子:4.04
ISSN:1750-743X
研究方向:医学-免疫学
影响因子:3.594
ISSN:1471-2172
研究方向:医学-免疫学
影响因子:2.211
ISSN:0198-8859
研究方向:医学-免疫学
影响因子:31.25
ISSN:1529-2908
研究方向:医学-免疫学
影响因子:4.23
ISSN:0165-2478
研究方向:医学-免疫学
影响因子:8.701
ISSN:1933-0219
研究方向:医学-免疫学
发表一篇学和医学成像类SCI论文
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