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Abstract:
CONTEXT:Thyroid autoimmunity (TAI), the most common cause of (sub)clinical hypothyroidism, is associated with adverse pregnancy outcomes. The benefits of levothyroxine (LT4) intervention in women with TAI remain controversial. OBJECTIVE:The purpose of this analysis is to determine the effect of LT4 on pregnancy outcomes in euthyroid women with TAI. DATA SOURCES:Databases were searched up to May 2019. STUDY SELECTION:Randomized controlled trails (RCTs) and retrospective studies that reported effects of LT4 administration on pregnancy outcomes in euthyroid women with TAI were screened. DATA EXTRACTION:Quality assessment and data extraction were conducted independently by 2 researchers. Conflicts were settled by a third researcher. DATA SYNTHESIS:Six trials comprising 2249 women were included. Overall, no beneficial effect on pregnancy outcomes was observed with LT4 supplementation. For women with individualized initial LT4 dosages, the risk of miscarriage decreased (relative risk [RR] 0.62, 95% CI: 0.41-0.93, I2 = 28%); there was no difference among women with fixed LT4 dosages (RR 0.96, 95% CI: 0.74-1.24, I2 = 0%). Women who initiated LT4 treatment in early pregnancy had a significantly lower preterm birth rate (RR 0.54, 95% CI: 0.31-0.92, I2 = 0%) than those who received no treatment or placebo. No improvement was observed among women who initiated treatment before conception (RR 1.14, 95% CI: 0.71-1.84, I2 = 0%). CONCLUSION:No definitive evidence showed improvement of pregnancy outcomes with LT4 supplementation in euthyroid women with TAI. However, therapeutic strategies, especially dosages and initial times of intervention, may be of great importance. Additional large RCTs are needed in the future.
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最新影响因子:6.134 | 期刊ISSN:0021-972X | CiteScore:0.0 |
出版周期:Monthly | 是否OA:YES | 出版年份:1952 |
自引率:4.00% | 研究方向:医学-内分泌学与代谢 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Clinical Endocrinology & Metabolism is the world''s leading peer reviewed journal of clinical practice and applied clinical research. Each issue provides fast and in depth coverage of diabetes, reproductive endocrinology, growth hormone therapy, thyroid disease, and other critical areas of clinical endocrinology. Regular features highlight current topics in clinical medicine, such as clinical studies, clinical case seminars, management of endocrine disorders, practice management issues, original patent oriented research studies, and other significant new endocrine studies related to human physiology and disease. According to the latest ISI Journal Citation Report, JCE&M articles were cited almost 38,000 times in 2000. It has the highest Impact Factor ranking (#9) of any clinical journal in the ISI category of endocrinology and metabolism.
《临床内分泌与代谢杂志》是世界领先的临床实践和应用临床研究的同行评审期刊。每个问题提供快速和深入的报道糖尿病,生殖内分泌学,生长激素治疗,甲状腺疾病和其他关键领域的临床内分泌。定期专题突出当前临床医学的主题,如临床研究、临床病例研讨会、内分泌疾病管理、实践管理问题、原始专利导向的研究,以及其他与人类生理和疾病相关的重要内分泌新研究。根据ISI期刊最新的引文报告,2000年,JCE&M的文章被引用了近3.8万次。在内分泌和代谢的ISI分类中,它是所有临床杂志中影响因子排名最高的(第9)。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 2区 |
20/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
491 | 476 | 15 |
引文计数(2018)
文献(2015-2017)
0次引用
99篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#208/209
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研究方向:代谢
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研究方向:代谢
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研究方向:甲状腺癌 临床 治疗
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:代谢
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研究方向:糖尿病手术
接受率: 比较困难(25%命中)
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研究方向:代谢
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研究方向:代谢
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研究方向:代谢
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研究方向:内分泌
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研究方向:代谢
审稿时间: 1个月内
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研究方向:diabetes thrombosis
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研究方向:代谢
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研究方向:代谢
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研究方向:代谢
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研究方向:糖尿病
接受率: 比较困难(25%命中)
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研究方向:甲状旁腺功能减退症 基因多态性 治疗
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研究方向:代谢
接受率: 比较困难(25%命中)
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研究方向:代谢
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研究方向:代谢
影响因子:0.889
ISSN:1370-6233
研究方向:AGRONOMY-ENVIRONMENTAL SCIENCES
影响因子:39.714
ISSN:1754-5692
研究方向:化学-工程:化工
影响因子:5.723
ISSN:0926-860X
研究方向:化学-环境科学
影响因子:14.224
ISSN:0304-3894
研究方向:工程技术-工程:环境
影响因子:0.158
ISSN:0949-8036
研究方向:工程技术-工程:环境
影响因子:2.472
ISSN:0028-1522
研究方向:ENGINEERING, AEROSPACE-REMOTE SENSING
影响因子:3.491
ISSN:0018-9251
研究方向:工程技术-电信学
影响因子:1.348
ISSN:1542-0973
研究方向:工程技术-电信学
影响因子:3.433
ISSN:2052-336X
研究方向:ENGINEERING, ENVIRONMENTAL-ENVIRONMENTAL SCIENCES
发表一篇学和医学成像类SCI论文
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