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Abstract:
OBJECTIVE:The objective of this study was to determine the impact of blood sample timing on the diagnosis of subclinical thyroid dysfunction (SCTD) and mortality in patients with acute myocardial infarction (AMI). PATIENTS, DESIGN, AND MAIN OUTCOME MEASURES:Patients with AMI had thyroid function evaluated on admission between December 2014 and December 2016 and those with abnormal serum thyrotropin (TSH) had repeat thyroid function assessed at least a week later. The association between sample timing and SCTD was evaluated by logistic regression analysis. Secondary outcomes were confirmation of SCTD on repeat testing and all-cause mortality up to June 2018. RESULTS:Of the 1806 patients [29.2% women, mean (± standard deviation) age of 64.2 (±12.1) years] analyzed, the prevalence of subclinical hypothyroidism (SCH) was 17.2% (n = 311) and subclinical hyperthyroidism (SHyper) was 1.2% (n = 22) using a uniform TSH reference interval. The risk of being diagnosed with SCTD varied by sample timing in fully-adjusted models. The risk of SCH was highest between 00.01 and 06.00 hours and lowest between 12.01 and 18.00 hours, P for trend <.001, and risk of SHyper was highest between 12.01 hours and 18.00 hours and lowest between 00.01 hours and 06.00 hours. Furthermore, time of the initial sample was associated with the risk of remaining in a SCH state subsequently. Mortality in SCH patients was not elevated when a uniform TSH reference interval was utilized. However, when time period-specific TSH reference ranges were utilized, the mortality risk was significantly higher in SCH patients with HR (95% CI) of 2.26 (1.01-5.19), P = .04. CONCLUSIONS:Sample timing impacts on the diagnosis and prognosis of SCH in AMI patients. If sample timing is not accounted for, SCH is systemically misclassified, and its measurable influence on mortality is lost.
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最新影响因子:6.134 | 期刊ISSN:0021-972X | CiteScore:0.0 |
出版周期:Monthly | 是否OA:YES | 出版年份:1952 |
自引率:4.00% | 研究方向:医学-内分泌学与代谢 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Clinical Endocrinology & Metabolism is the world''s leading peer reviewed journal of clinical practice and applied clinical research. Each issue provides fast and in depth coverage of diabetes, reproductive endocrinology, growth hormone therapy, thyroid disease, and other critical areas of clinical endocrinology. Regular features highlight current topics in clinical medicine, such as clinical studies, clinical case seminars, management of endocrine disorders, practice management issues, original patent oriented research studies, and other significant new endocrine studies related to human physiology and disease. According to the latest ISI Journal Citation Report, JCE&M articles were cited almost 38,000 times in 2000. It has the highest Impact Factor ranking (#9) of any clinical journal in the ISI category of endocrinology and metabolism.
《临床内分泌与代谢杂志》是世界领先的临床实践和应用临床研究的同行评审期刊。每个问题提供快速和深入的报道糖尿病,生殖内分泌学,生长激素治疗,甲状腺疾病和其他关键领域的临床内分泌。定期专题突出当前临床医学的主题,如临床研究、临床病例研讨会、内分泌疾病管理、实践管理问题、原始专利导向的研究,以及其他与人类生理和疾病相关的重要内分泌新研究。根据ISI期刊最新的引文报告,2000年,JCE&M的文章被引用了近3.8万次。在内分泌和代谢的ISI分类中,它是所有临床杂志中影响因子排名最高的(第9)。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 2区 |
20/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
491 | 476 | 15 |
引文计数(2018)
文献(2015-2017)
0次引用
99篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#208/209
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研究方向:代谢
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研究方向:代谢
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研究方向:甲状腺癌 临床 治疗
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:代谢
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研究方向:糖尿病手术
接受率: 比较困难(25%命中)
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研究方向:代谢
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研究方向:内分泌
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研究方向:代谢
审稿时间: 1个月内
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研究方向:diabetes thrombosis
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研究方向:代谢
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研究方向:代谢
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研究方向:糖尿病
接受率: 比较困难(25%命中)
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研究方向:甲状旁腺功能减退症 基因多态性 治疗
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研究方向:代谢
接受率: 比较困难(25%命中)
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研究方向:代谢
影响因子:2.566
ISSN:0739-7240
研究方向:农林科学-奶制品与动物科学
影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
影响因子:1.297
ISSN:0028-2804
研究方向:医学-精神病学
影响因子:4.604
ISSN:1092-8529
研究方向:医学-精神病学
影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
ISSN:0269-8811
研究方向:医学-精神病学
影响因子:6.533
ISSN:0165-0327
研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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