发表一篇学和医学成像类SCI论文
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Abstract:
OBJECTIVES:Multiple myeloma (MM) is characterized by malignant growth of plasma cells, usually producing a monoclonal antibody (mAb). New treatments for MM include therapeutic monoclonal antibodies (tmAbs), but patients treated with tmAb demonstrate interference on serum electrophoresis (SPE) and immunoprecipitation electrophoresis (IEP). Evaluation of treatment efficacy and determination of MM remission include SPE and IEP which identifies mAb, but cannot differentiate between disease associated mAb and tmAb. We hypothesized that tmAb could be removed from patient sera before testing by SPE and IEP to provide accurate diagnoses for clinicians. DESIGN AND METHODS:We developed the Antigen Specific therapeutic monoclonal Antibody Depletion Assay (ASADA), that utilizes magnetic beads coated with the cognate antigen of the tmAbs, to deplete two different tmAb (daratumumab, elotuzumab) from saline and patient sera and assessed for complete removal of tmAb by SPE and IEP. RESULTS:We found that tmAb could be efficiently removed from saline and patient sera. ASADA demonstrated acceptable analytical specificity and sensitivity in IEP. Recovery of appropriate quantitative values by SPE was demonstrated with clinically acceptable precision. A single bead cocktail could be used to treat both daratumumab and elotuzumab. CONCLUSIONS:This demonstrates proof of principle that ASADA can be used to remove current and future tmAb from patient sera, regardless of platform. This research provides for accurate diagnosis, disease monitoring, and remission status in MM patients being treated with tmAb.
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最新影响因子:3.625 | 期刊ISSN:0009-9120 | CiteScore:2.35 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1967 |
期刊官方网址:http://www.journals.elsevier.com/clinical-biochemistry/
自引率:6.30% | 研究方向:医学-医学实验技术 |
出版地区:CANADA |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Clinical Biochemistry publishes articles relating to the applications of molecular biology, biochemistry, chemistry and immunology to clinical investigation and to the diagnosis, therapy, and monitoring of human disease. Manuscripts are categorized as Analytical or Clinical Investigations and may be offered as Full Papers or as Capsules. Critical Reviews are welcome, but contributors are encouraged to contact the Editor-in-Chief to avoid conflict with other forthcoming Reviews.
临床生物化学发表有关分子生物学、生物化学、化学和免疫学在临床研究、诊断、治疗和监测人类疾病中的应用的文章。手稿被分类为分析或临床调查,并可提供完整的论文或胶囊。我们欢迎批评性的评论,但也鼓励投稿者联系总编,避免与其他即将发表的评论发生冲突。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICAL LABORATORY TECHNOLOGY (医学实验技术) 3区 |
13/30 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
213 | 190 | 23 |
引文计数(2018)
文献(2015-2017)
1991次引用
846篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Clinical Biochemistry
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研究方向:生命科学 微生物学 病毒学
审稿时间: 2个月内
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研究方向:临床检验
审稿时间: 3个月内 接受率: 比较困难(25%命中)
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接受率: 比较困难(25%命中)
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审稿时间: 3个月内
影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
影响因子:1.297
ISSN:0028-2804
研究方向:医学-精神病学
影响因子:4.604
ISSN:1092-8529
研究方向:医学-精神病学
影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
ISSN:0269-8811
研究方向:医学-精神病学
影响因子:6.533
ISSN:0165-0327
研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
影响因子:2.493
ISSN:0925-4927
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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