发表一篇学和医学成像类SCI论文
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Abstract:
OBJECTIVES/HYPOTHESIS:To evaluate if a simple method for assessing tumor-infiltrating lymphocytes (TIL) in primary tumor specimens improves the prognostic value of the American Joint Committee on Cancer, 8th Edition (AJCC8) cancer staging system in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPC). STUDY DESIGN:Retrospective study. METHODS:In this study, TIL density was quantified on hematoxylin and eosin (H&E)-stained specimens from patients presenting to Johns Hopkins Hospital between 2009 and 2017 who underwent primary surgical therapy and had primary tumor specimens available for analysis. The prognostic effect of TIL density was evaluated by Kaplan-Meier method and Cox proportional hazards models considering recurrence-free survival (RFS) as the primary outcome. RESULTS:This study included 132 patients. Ninety-five percent were classified by clinical criteria with AJCC8 early-stage disease (stage I: 82%, stage II: 13%). After 84 months of follow-up, 15 recurrences were observed. Among clinically early-stage disease, TILhigh status was associated with improved RFS compared to TILlow (P = .002). Adjusted analysis showed TILhigh status was associated with 79% lower risk of recurrence than TILlow (adjusted hazard ratio [aHR]: 0.210, 95% confidence interval [CI]: 0.061-0.723). In clinical stage I disease, TILhigh status was associated with improved RFS compared to TILlow in both univariate and multivariate analyses (hazard ratio: 0.235, P = .021; aHR: 0.218; 95% CI: 0.058-0.822). TIL density similarly stratified risk in pathologically staged disease. CONCLUSIONS:In patients with AJCC8 stage I disease, low TIL density was associated with diminished RFS. Our data suggest that assessing TIL density on H&E-stained primary tumor specimens may enhance the prognostic resolution of the AJCC8 staging criteria for HPV-OPC. LEVEL OF EVIDENCE:4 Laryngoscope, 130:930-938, 2020.
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最新影响因子:2.97 | 期刊ISSN:0023-852X | CiteScore:2.37 |
出版周期:Monthly | 是否OA:YES | 出版年份:1896 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291531-4995
自引率:10.50% | 研究方向:医学-耳鼻喉科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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For more than 100 years, otolaryngologists, clinicians, and researchers around the world have read The Laryngoscope to keep pace with and learn how to take advantage of the most important advances in the diagnosis and treatment of head and neck disorders. Moreover, the journal is the first choice among otolaryngologists to publish their most important findings and share their own successful techniques with their colleagues.
100多年来,世界各地的耳鼻喉科医生、临床医生和研究人员都阅读喉镜,以跟上并学习如何利用头颈部疾病诊断和治疗方面最重要的进展。此外,该杂志是耳鼻喉科医生的第一选择,发表他们最重要的发现,并与他们的同事分享他们自己的成功技术。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 4区 OTORHINOLARYNGOLOGY (耳鼻喉科学) 3区 |
73/133 12/41 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
483 | 442 | 41 |
引文计数(2018)
文献(2015-2017)
4357次引用
1837篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Otorhinolaryngology
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发表一篇学和医学成像类SCI论文
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