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Abstract:
Arsenic-contaminated drinking water is known to be a serious human health problem. A previous epidemiological study has indicated that arsenic levels in blood were higher in arthritis patients compared to age-matched control subjects. Bone is known as an important arsenic store compartment in the body. Arsenic exposure has been suggested to promote senescence in human mesenchymal stem cells that may affect the balance of adipogenic and osteogenic differentiation. The toxicological effect and mechanism of arsenic exposure on articular chondrocytes still remain unclear. Here, we investigated the arsenic-induced senescence in cultured human articular chondrocytes and long-term arsenic-exposed rat articular cartilage. Arsenic trioxide (As_2O_3; 1–5 μM) significantly induced senescence in human articular chondrocytes by increasing senescence-associated β-galactosidase (SA-β-Gal) activity and protein expression of p16, p53, and p21. Arsenic induced the phosphorylation of p38 and c-Jun N-terminal kinase (JNK) proteins. The inhibitors of p38 and JNK significantly reversed the arsenic-induced chondrocyte senescence. Arsenic could also trigger the induction of GATA4-NF-κB signaling and senescence-associated secretory phenotype (SASP) by increasing IL-1α, IL-1β, TGF-β, TNF-α, CCL2, PAI-1, and MMP13 mRNA expression. The increased cartilage senescence and abrasion were also observed in a rat model long-term treatment with arsenic (0.05 and 0.5 ppm) in drinking water for 36 weeks as compared to age-matched control rats. The phosphorylation of p38 and JNK and the induction of GATA4-NF-κB signaling and SASP were enhanced in the rat cartilages. Taken together, these findings suggest that arsenic exposure is capable of inducing chondrocyte senescence and accelerating rat articular cartilage aging and abrasion.
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最新影响因子:6.168 | 期刊ISSN:0340-5761 | CiteScore:4.79 |
出版周期:Monthly | 是否OA:YES | 出版年份:1974 |
自引率:8.50% | 研究方向:医学-毒理学 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Official journal of EUROTOX Edited on behalf of the Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie The provision of up-to-date information on the latest advances in toxicology is one of the main services that Archives of Toxicology offers its readers. Particular emphasis is laid on studies relating to defined effects of chemicals and mechanisms of toxicity including toxic activities at the molecular level in humans and experimental animals. Space is also devoted to new insights into analysis and toxicokinetics and to forensic toxicology. Review articles of general interest to toxicologists are a further important feature of the journal. Experimental and clinical data relating to toxicology can be submitted for publication in Archives of Toxicology as Original investigations Review articles Short communications or Letters to the editors
《欧洲毒理学》官方期刊是代表德国格列斯沙夫毛皮实验与毒理学研究所编辑的,提供毒理学最新进展的最新信息是毒理学档案为读者提供的主要服务之一。特别强调的是关于化学物质的明确影响和毒性机制的研究,包括在人类和实验动物分子一级的毒性活动。空间也致力于分析和毒物动力学和法医毒理学的新见解。毒理学家普遍感兴趣的综述文章是该杂志的另一个重要特征。与毒理学有关的实验和临床数据可作为原始调查综述文章提交毒理学档案,或作为简短的通信或信件发送给编辑
大类(学科) | 小类(学科) | 学科排名 |
医学 |
TOXICOLOGY (毒理学) 2区 |
7/94 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
257 | 212 | 45 |
引文计数(2018)
文献(2015-2017)
3002次引用
627篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Toxicology
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#9/111
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2 |
大类(学科):Environmental Science
小类(学科):Health, Toxicology and Mutagenesis
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#11/107
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研究方向:毒理
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研究方向:毒理
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研究方向:化学科学 环境化学 化学环境污染与健康
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研究方向:医药科学 预防医学 卫生毒理
审稿时间: 2个月内
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研究方向:毒理
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研究方向:毒理
影响因子:2.566
ISSN:0739-7240
研究方向:农林科学-奶制品与动物科学
影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
影响因子:1.297
ISSN:0028-2804
研究方向:医学-精神病学
影响因子:4.604
ISSN:1092-8529
研究方向:医学-精神病学
影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
ISSN:0269-8811
研究方向:医学-精神病学
影响因子:6.533
ISSN:0165-0327
研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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