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Abstract:
OBJECTIVES:We investigated the diagnostic efficacy of the prostate health index (PHI) and PHI density (PHID) to avoid unnecessary prostate biopsies in 3 urological practices. METHODS:In 122 patients, total prostate-specific antigen (PSA), free PSA (f-PSA), the quotient from total PSA and f-PSA (f-PSA%), and [-2]pro-PSA were measured in the serum; PHI, PHID, and PSA density (PSAD) were calculated prior to prostate biopsy. Tissue sampling via transrectal biopsy was indicated in case of suspicious PSA (progression and/or elevation of PSA) and/or suspicious digital rectal examination. PSAD, PHI, and PHID were not used for biopsy indication. The diagnostic efficacy was determined with receiver-operating characteristic (ROC)and decision curve analyses. RESULTS:Based on prostate biopsies, 38% (n = 46) of the cases had no prostate carcinoma (PCa), 21% (n = 26) no clinically significant (insignificant) PCa, and 41% (n = 50) had clinically significant PCa. ROC analyses of the PSA parameters showed higher diagnostic efficacy for PHI and PHID (AUC 0.722 and 0.739) than for f-PSA%, PSA, and PSAD (AUC 0.612, 0.595, and 0.698, respectively) regarding carcinoma diagnosis. With a combined use of PHI and PHID (cutoff >40 and >0.9, respectively), only 1 clinically significant PCa would have been missed (sensitivity 98%); in 24 (20%) patients, biopsy could have been avoided. CONCLUSION:The integration of PHI and PHID could improve the diagnostic efficacy of risk calculators to avoid unnecessary prostate biopsies. However, as a prerequisite, validation of cutoff values in prospective studies is urgently required.
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最新影响因子:1.934 | 期刊ISSN:0042-1138 | CiteScore:1.42 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1955 |
自引率:23.70% | 研究方向:医学-泌尿学与肾脏学 |
出版地区:SWITZERLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Concise but fully substantiated international reports of clinically oriented research into the etiology, pathophysiology and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. An expert discussion panel provides an international forum for exchanging ideas on the current management of clinical and technical problems of urologic surgery. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.
关于泌尿生殖系统疾病的病因学、病理生理学和当前管理的临床导向研究的简明而充分的国际报告构成了原始和基础研究论文的核心。此外,国际专家还对临床泌尿外科实践的关键课题进行了最新的综述。定期报道的基本主题包括新技术和仪器的介绍以及新功能测试和诊断方法的评估。特别关注外科技术和临床肿瘤学的进展。一个专家讨论小组提供了一个国际论坛,就当前泌尿外科临床和技术问题的管理交换意见。定期出版选定的病例报告代表了泌尿系统疾病的巨大差异,并说明了在个别病例的治疗方案。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
UROLOGY & NEPHROLOGY (泌尿学与肾脏学) 4区 |
54/76 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
144 | 122 | 22 |
引文计数(2018)
文献(2015-2017)
687次引用
485篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Urology
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#44/97
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影响因子:2.438
ISSN:0261-1929
研究方向:农林科学-兽医学
影响因子:3.025
ISSN:1094-7159
研究方向:医学-临床神经学
影响因子:4.169
ISSN:0264-410X
研究方向:医学-免疫学
影响因子:17.579
ISSN:0022-1007
研究方向:医学-免疫学
影响因子:5.274
ISSN:0971-5916
研究方向:医学-免疫学
影响因子:4.061
ISSN:2314-6745
研究方向:ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EX
影响因子:2.976
ISSN:0914-8779
研究方向:医学-内分泌学与代谢
影响因子:4.75
ISSN:0141-8955
研究方向:医学-内分泌学与代谢
影响因子:10.171
ISSN:1931-5244
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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