Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer's Disease and Vascular Dementia.

e

Abstract:

:Uric acid (UA) is a major contributor to naturally-occurring antioxidant activity and is thought to have protective effects against neurodegenerative processes. However, UA is also implicated as a risk factor in vascular, including cerebrovascular, disease. Its association with, and role in, dementia and its component diseases including Alzheimer's disease (AD) and vascular dementia (VaD) remains unclear and inconsistently studied. Changes in blood lipids, particularly cholesterol measures, have also been implicated in dementias although the relationship or interactions with UA have been little studied.We have measured plasma UA and lipids taken from 187 subjects first attending a general hospital neurology department for symptoms associated with dementia, and from a series of 79 healthy control subjects. Diagnoses of AD and VaD were made following neuroimaging; laboratory measures were compared between dementia and control groups and between AD and VaD subgroups. No overall change in UA was seen in dementia, although a substantial and highly significant reduction was found in the AD patients. Reduced values in total cholesterol, HDL, and LDL were found in dementia, independent of statin treatment. Further investigation found a significant reduction of HDL only in the VaD group, while total cholesterol was significantly reduced in both AD and VaD subjects.These findings indicate that in our Chinese sample, UA deficits are specifically associated with AD, while deficits in HDL cholesterol found in dementia tend to be greater in VaD.

尿酸和高密度脂蛋白胆固醇与阿尔茨海默病和血管性痴呆有不同的相关性。

c

摘要:

: 尿酸 (UA) 是天然抗氧化活性的主要贡献者,被认为对神经退行性疾病有保护作用。然而,UA 也被认为是包括脑血管疾病在内的血管疾病的危险因素。它与痴呆及其组分疾病 (包括阿尔茨海默病 (AD) 和血管性痴呆 (VaD)) 的关联和作用仍不清楚,研究不一致。血脂,特别是胆固醇指标的变化也与痴呆有关,尽管与 UA 的关系或相互作用鲜有研究。我们测量了 187 例首次因痴呆相关症状就诊于综合医院神经科的受试者和 79 例健康对照受试者的血浆 UA 和血脂。神经影像学检查后诊断 AD 和 VaD; 比较痴呆组和对照组之间以及 AD 和 VaD 亚组之间的实验室指标。虽然在 AD 患者中发现大量且高度显著的减少,但在痴呆患者中未观察到 UA 的总体变化。发现痴呆患者总胆固醇、 HDL 和 LDL 值降低,与他汀类药物治疗无关。进一步研究发现,仅 VaD 组 HDL 显著降低,而 AD 和 VaD 受试者的总胆固醇均显著降低。这些发现表明,在我们的中国样本中,UA 缺陷与 AD 特异性相关,而在痴呆中发现的 HDL 胆固醇缺陷在 VaD 中往往更大。

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JOURNAL OF ALZHEIMERS DISEASE

研究方向:医学-神经科学
IF:4.671
IF值的bai意思是影响因子。是汤森路透(duThomson Reuters)出品的期刊引证报告zhi(Journal Citation Reports,JCR)中的一项数据。 影响因子dao目前的计算方法是:IF=C/(M+N)。以2017年IF的计算为例,M为该期刊2015年发表的文章数量,N为该期刊2016年发表的文章数量,C为该期刊2015和2016年两年发表的文章在2017年这一年被引用的
出版周期: NETHERLANDS
中科院分区:Q4 来稿接收率:约 % 审稿周期:平均2月
11.70%
YES
1998
1387-2877
出版地区: CiteScore:
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JOURNAL OF ALZHEIMERS DISEASE 期刊简介

英文简介:

Published by IOS Press. ISSN: 1387-2877. The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.

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中文简介

由IOS出版社出版。ISSN: 1387 - 2877。 《阿尔茨海默病杂志》是一份国际性的多学科期刊,旨在促进对阿尔茨海默病的病因、发病机制、流行病学、遗传学、行为、治疗和心理学的理解。该杂志出版研究报告、评论、简短的交流、书评和给编辑的信件。该杂志致力于为原始研究提供一个开放的论坛,将加快我们对阿尔茨海默病的基本认识。

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JOURNAL OF ALZHEIMERS DISEASE期刊中科院评价数据

最新中科院JCR分区

大类(学科) 小类(学科) 学科排名
医学 NEUROSCIENCES(神经系统科学) 3区
96/261

最新公布的期刊年发文量

年度总发文量 年度论文发表量 年度综述发表量
736 660 76

总被引频次: 20383

特征因子: 0.041470

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JOURNAL OF ALZHEIMERS DISEASE期刊CiteScore评价数据

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=

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=

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被引比率: %

SJR:
SCLmago期刊等级衡量经过加权后的期刊受引用次数,引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP:
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
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