Prospective evaluation of XRCC-1 Arg194Trp polymorphism as bio-predictor for clinical outcome in locally advanced laryngeal cancer undergoing cisplatin-based chemoradiation.

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Abstract:

BACKGROUND:To determine X-ray repair cross-complementing 1 gene (XRCC-1) Arg194Trp polymorphism as bio-predictor for clinical outcome in advanced laryngeal squamous cell carcinoma undergoing cisplatin-based chemoradiation (CRT). METHODS:A total of 150 patients were enrolled in this prospective study. XRCC-1 Arg194Trp genotyping categorized patients as wild (C/C) and polymorphic (C/T or T/T). The primary endpoint was to assess acute radiation-induced toxicity (ARIT). RESULTS:A significant correlation of skin (P- .04) and oral mucosal ARIT (P- .01) was noticed in the XRCC-1 polymorphic variant. A higher treatment response was noted in the polymorphic variant, and it shows a trend toward significance (P- .08). With 33 months of median follow-up, 2-year progression-free survival (PFS) and overall survival (OS) of wild vs polymorphic variant were 34.6% vs 46.9% (P- .066) and 50.6% vs 62.2% (P- .12). CONCLUSION:XRCC-1 polymorphic variants have significantly higher grade of >2 ARIT and may have improved trend for treatment response and PFS.

XRCC-1 Arg194Trp 多态性作为局部晚期喉癌接受以顺铂为基础的放化疗临床结局生物预测因子的前瞻性评价。

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摘要:

背景: 确定 x线修复交叉互补 1 基因 (XRCC-1) Arg194Trp 多态性作为晚期喉鳞状细胞癌接受以顺铂为基础的放化疗 (CRT) 临床结局的生物预测因子。 方法: 本前瞻性研究共纳入 150 例患者。XRCC-1 Arg194Trp 基因分型将患者分为野生型 (C/C) 和多态性型 (C/T 或 T/T)。主要终点是评估急性辐射诱导毒性 (ARIT)。 结果: 在 XRCC-1 多态性变异中,皮肤 (P-.04) 和口腔黏膜 ARIT (P-.01) 显著相关。在多态变异中观察到更高的治疗反应,并显示出显著性趋势 (P-.08)。33 个月的中位随访,野生型 vs 多态变异的 2 年无进展生存期 (PFS) 和总生存期 (OS) 分别为 34.6% vs 46.9% (P-. 066) 和 50.6% vs 62.2% (P-。 12)。 结论: XRCC-1 多态性变异> 2 ARIT 分级明显增高,治疗反应和 PFS 可能有改善趋势。

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HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

研究方向:医学-耳鼻喉科学
IF:3.147
IF值的bai意思是影响因子。是汤森路透(duThomson Reuters)出品的期刊引证报告zhi(Journal Citation Reports,JCR)中的一项数据。 影响因子dao目前的计算方法是:IF=C/(M+N)。以2017年IF的计算为例,M为该期刊2015年发表的文章数量,N为该期刊2016年发表的文章数量,C为该期刊2015和2016年两年发表的文章在2017年这一年被引用的
出版周期: UNITED STATES
中科院分区:Q4 来稿接收率:约 % 审稿周期:平均1.6月
9.30%
YES
1989
1043-3074
出版地区: CiteScore:

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HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 期刊简介

英文简介:

Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties including general surgery neurosurgery otolaryngology plastic surgery oral surgery dermatology ophthalmology pathology radiotherapy medical oncology and the corresponding basic sciences. Head & Neck publishes original contributions on clinical and research topics. Each manuscript is submitted to peer review by at least two experts in the field. Comprehensive reviews of topics particularly in fields subject to rapid change in knowledge will be included at the discretion of the Editor and on the recommendation of reviewers. Technical notes descriptions of new technologies single case reports of unusual interest and brief preliminary communications are accepted after proper peer review. Editorials and Letters to the Editor are also considered for publication. Head & Neck also publishes regular series: Controversies Basic Science Reviews Anatomic Correlates Abstracts and Book Reviews . Book Reviews are solicited by the editor and publishers should send review books to Randal S. Weber MD Editor. Visual materials will also be accepted for review. Head & Neck adheres to the Uniform Requirements for Manuscripts Submitted to Biomedical Journals under the agreement of the International Committee of Medical Journal Editors ( JAMA 1993;269:2282-2286). Manuscripts are accepted for consideration if they have not appeared elsewhere in any but abstract form and are not currently under consideration for publication elsewhere. This policy does not preclude consideration of a manuscript that has been rejected by another journal or of a complete report that follows publication of the preliminary report or abstract. It is requested that the author submit a full statement to the Editor about previous reports that may be regarded as prior or duplicate publication for the same or similar work. Multiple-part publications are discouraged. Secondary publications in another language will be considered individually. Preliminary release of data usually to public media of scientific information described in a paper may be acceptable but should be discussed with the Editor.

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中文简介

《头颈部》是一本关于头颈部疾病诊断和管理的原始贡献的国际多学科出版物。这一领域涉及普通外科、神经外科、耳鼻喉科、整形外科、口腔外科、皮肤科、眼科、病理学、放射治疗、医学肿瘤学和相应的基础科学等多个外科和医学专业的交叉兴趣和专长《头颈部》出版了关于临床和研究主题的原创文章。每一份手稿都由该领域至少两名专家提交同行评审。编辑可自行决定并根据评审员的建议对专题进行全面审查,尤其是在知识迅速变化的领域。在适当的同行评审后,接受新技术的技术说明、异常兴趣的单一案例报告和简短的初步沟通。社论和致编辑的信也被考虑出版。《头颈部》出版常规系列:争议基础科学评论解剖学相关摘要和书评。编辑征集书评,出版商应将评论书发送给Randal S. Weber MD编辑。视觉材料也将接受审查。根据国际医学期刊编辑委员会的协议,头颈部遵守提交给生物医学期刊的手稿的统一要求(JAMA 1993; 269:2282-2286)。如果稿件没有以任何抽象形式出现在其他地方,并且目前正在考虑在其他地方出版,则可以接受审稿。本政策不排除考虑已被其他期刊拒绝的稿件或在初步报告或摘要发布后的完整报告。要求作者向编辑提交关于之前报告的完整陈述,这些报告可能被视为相同或类似作品的先前或重复出版物。不鼓励多部分出版物。另一种语言的二级出版物将单独考虑。通常向论文中描述的科学信息的公共媒体初步发布数据可能是可以接受的,但应与编辑讨论。

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HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK期刊中科院评价数据

最新中科院JCR分区

大类(学科) 小类(学科) 学科排名
医学 OTORHINOLARYNGOLOGY(耳鼻喉科学) 2区
SURGERY(外科学) 3区
9/41
65/200

最新公布的期刊年发文量

年度总发文量 年度论文发表量 年度综述发表量
338 303 35

总被引频次: 11100

特征因子: 0.018120

近年影响因子趋势图

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK期刊CiteScore评价数据

最新CiteScoere值

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引文计数(2018)

文献(2015-2017)

=

次引用

篇文献

文献总数(2014-2016):

被引比率: %

SJR:
SCLmago期刊等级衡量经过加权后的期刊受引用次数,引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP:
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
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