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Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer.
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Abstract:
BACKGROUND & AIMS:Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. METHODS:We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary Study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants. RESULTS:Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction = .01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95% CI 3.28-4.24) vs 2.9-fold for late-onset CRC (95% CI 2.80-3.04). This association was strongest for participants without a first-degree family history of CRC (P for interaction = 5.61 × 10-5). When we compared the highest with the lowest quartiles in this group, risk increased 4.3-fold for early-onset CRC (95% CI 3.61-5.01) vs 2.9-fold for late-onset CRC (95% CI 2.70-3.00). Sensitivity analyses were consistent with these findings. CONCLUSIONS:In an analysis of associations with CRC per standard deviation of PRS, we found the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive measures.
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GASTROENTEROLOGY
GASTROENTEROLOGY
| 最新影响因子：33.883 | 期刊ISSN：0016-5085 | CiteScore：6.95 |
| 出版周期：Monthly | 是否OA：YES | 出版年份：1943 |
| 自引率：3.70% | 研究方向：医学-胃肠肝病学 |
| 出版地区：UNITED STATES |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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GASTROENTEROLOGY 期刊简介
英文简介：
Gastroenterology is the most prominent journal in the field of gastrointestinal disease. As the official journal of the American Gastroenterological Association, Gastroenterology delivers up-to-date, authoritative, clinically oriented coverage of all areas in gastroenterology. Regular features include articles by leading authorities, reports on the latest treatments for diseases, and an exclusive correspondence section. Gastroenterology is organized into the following sections to make material easy to find: Alimentary Tract; Liver, Pancreas and Biliary Tract; Case Reports; Special Reports and Reviews; and a section on Clinical Challenges which presents more in-depth information on how a diagnosis is reached. An additional feature is the Image of the Month.
中文简介：（来自Google、百度翻译）
胃肠病学是胃肠疾病领域最著名的期刊。作为美国胃肠病学协会的官方杂志，胃肠病学提供最新的，权威的，以临床为导向的胃肠病学的所有领域的报道。定期的特写包括由权威机构撰写的文章，关于疾病的最新治疗方法的报道，以及一个独家的通讯栏目。胃肠病学分为以下几个部分，使材料容易找到:消化道;肝脏、胰腺和胆道;病例报告;特别报告和审查;还有一个关于临床挑战的章节，提供了关于如何做出诊断的更深入的信息。另外一个特性是该月的图像。
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GASTROENTEROLOGY 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
GASTROENTEROLOGY & HEPATOLOGY (胃肠肝病学) 1区 |
1/80 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 278 | 251 | 27 |
总被引频次：74469
特征因子：0.104920
影响因子趋势图
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GASTROENTEROLOGY 期刊CiteScore评价数据
最新CiteScore值
6.95
=
引文计数(2018)
文献(2015-2017)
=
13021次引用
1874篇文献
文献总数（2014-2016）：1874
被引比率：54%
SJR：7.958
SCLmago期刊等级衡量经过加权后的期刊受引用次数，引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP：3.573
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Medicine
小类(学科)：Hepatology
|
#0/59
点击查看排名表
|
|
| 2 |
大类(学科)：Medicine
小类(学科)：Gastroenterology
|
#2/128
点击查看排名表
|
|
CiteScore趋势图
Scopus涵盖范围
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最新评论(不代表本站观点)
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liting7111
研究方向：淋巴瘤
接受率： 一般容易（75%命中）
投了篇病例报告，去年圣诞节前投稿，月底修改格式，今年2月8号接受了。2020-06-18 -
liting7111
研究方向：医药科学 消化系统 肝胆胰免疫及相关疾病
审稿时间： 1个月内
最近好不容易接收一篇。投稿文章需要有明显的临床指导意义，还需要大量的临床数据支撑机制研究，修改补实验5个月接收，跟投稿前多了一倍的数据量。2020-06-02 -
liting7111
研究方向：消化病 胃肠道
接受率： 比较困难（25%命中）
投了篇meta分析，一周拒稿，拒稿理由是，一月份有篇文章跟你的相似。2020-03-24 -
liting7111
研究方向：胰腺癌
审稿时间： 2个月内 接受率： 比较困难（25%命中）
速度很快，刚接收。我在1月份投稿，两个月就给了一审大修，花了五个月不到时间投回，二审一个月后就回来了，修改几个小问题，两周顺利接收。2020-03-24 -
liting7111
研究方向：消化病 胃肠道
接受率： 比较困难（25%命中）
顺利接收，投稿两周时告知临时接收，投回去给了小修，修改后再投四天接收。效率很高的杂志。2019-10-22
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