发表一篇学和医学成像类SCI论文
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Abstract:
:Monocytes polarize into pro-inflammatory macrophage-1 (M1) or alternative macrophage-2 (M2) states with distinct phenotypes and physiological functions. M2 cells promote tumour growth and metastasis whereas M1 macrophages show anti-tumour effects. We found that M2 cells were increased whereas M1 cells were decreased in bone marrow (BM) from multiple myeloma (MM) patients with progressive disease (PD) compared to those in complete remission (CR). Gene expression of Tribbles homolog 1 (TRIB1) protein kinase, an inducer of M2 polarization, was increased in BM from MM patients with PD compared to those in CR. Ruxolitinib (RUX) is an inhibitor of the Janus kinase family of protein tyrosine kinases (JAKs) and is effective for treating patients with myeloproliferative disorders. RUX markedly reduces both M2 polarization and TRIB1 gene expression in MM both in vitro and in vivo in human MM xenografts in severe combined immunodeficient mice. RUX also downregulates the expression of CXCL12, CXCR4, MUC1, and CD44 in MM cells and monocytes co-cultured with MM tumour cells; overexpression of these genes is associated with resistance of MM cells to the immunomodulatory agent lenalidomide. These results provide the rationale for evaluation of JAK inhibitors, including MM BM in combination with lenalidomide, for the treatment of MM patients.
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最新影响因子:8.615 | 期刊ISSN:0007-1048 | CiteScore:3.43 |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1955 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291365-2141
自引率:5.10% | 研究方向:医学-血液学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Official Journal of the British Society for Haematology and the European Haematology Association. The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, rapid papers of special scientific importance, short reports, Letters to the Editor and book reviews. In addition, the Journal publishes, in supplement form, abstracts of the meetings of the British Society for Haematology and the European Haematology Association.
英国血液学协会和欧洲血液学协会的官方期刊。英国血液学杂志在临床,实验室和实验血液学发表原始研究论文。该杂志还提供注释、评论、具有特殊科学重要性的快速论文、简短的报告、给编辑的信和书评。此外,该杂志以补充形式出版了英国血液学学会和欧洲血液学协会会议摘要。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 2区 |
12/71 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
306 | 230 | 76 |
引文计数(2018)
文献(2015-2017)
5189次引用
1513篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hematology
|
#21/120
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研究方向:医学 血液学
审稿时间: 3个月内
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研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
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研究方向:医学-医学:内科
影响因子:0.522
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研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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