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Abstract:
BACKGROUND:The standard diagnostic criteria for hemophagocytic lymphohystiocytosis (HLH) include hyperferritinemia to > 500ng/ml. This ferritin threshold is based on pediatric data, and evidence for its application among adults with secondary HLH is lacking. OBJECTIVE AND METHODS:We conducted a retrospective study assessing the relationship between extreme hyperferritinemia and adult secondary HLH at our institution. All adult inpatients seen over a 10 year period, with serum ferritin >5,000ng/ml were included. RESULTS:Among 1055 patients with serum ferritin >5,000ng/ml there were 69 cases of HLH (HLH prevalence of 6.5%). Mean ferritin among HLH patients was 70,398ng/ml (SD 122,908), median 40,019ng/ml (IQR 16,051 - 68,326). The prevalence of HLH only reached 50% as serum ferritin approached 90,000ng/ml. A variety of conditions were contributory to hyperferritinemia, most commonly bacterial sepsis (33%), hematologic malignancy (29%), renal failure (24%), and liver injury (18%). The optimal cutoff ferritin for diagnosis of HLH was 16000ng/ml (sensitivity 79.4%, specificity of 79.2% , PPV 20.9%, NPV 98.2%). CONCLUSIONS:The threshold ferritin levels used in diagnostic criteria for adult secondary HLH are too low to be clinically relevant and efforts should be undertaken to revise them upward. Similar reappraisals should be taken of the other criteria used to diagnose adult HLH.
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最新影响因子:3.674 | 期刊ISSN:0902-4441 | CiteScore:2.19 |
出版周期:Monthly | 是否OA:YES | 出版年份:1987 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0609
自引率:4.20% | 研究方向:医学-血液学 |
出版地区:DENMARK |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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European Journal of Haematology is an international journal for communication of basic and clinical research in haematology. The journal welcomes manuscripts on molecular cellular and clinical research on diseases of the blood vascular and lymphatic tissue and on basic molecular and cellular research related to normal development and function of the blood vascular and lymphatic tissue. The journal furthermore welcomes reviews on clinical haematology and basic research case reports and clinical pictures.
《欧洲血液学杂志》是一本关于血液学基础和临床研究交流的国际性杂志。欢迎有关血管和淋巴组织疾病的分子细胞和临床研究手稿,以及有关血管和淋巴组织正常发育和功能的基本分子和细胞研究手稿。此外,该杂志还欢迎对临床血液学和基础研究病例报告和临床图片的评论。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 3区 |
36/71 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
158 | 143 | 15 |
引文计数(2018)
文献(2015-2017)
1181次引用
539篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hematology
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#42/120
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发表一篇学和医学成像类SCI论文
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