发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND:The impact of anaesthetic techniques on recurrence of cancers is controversial. Elevated plasma catecholamine levels have been implicated in angiogenesis and metastasis in various cancers. OBJECTIVES:To assess the potential association between continuous intra-operative norepinephrine administration and tumour-related outcome in muscle-invasive bladder cancer patients undergoing radical cystectomy with urinary diversion. DESIGN:Retrospective observational cohort study. SETTING:Single tertiary centre, from 2000 to 2017. PATIENTS:We included a consecutive series of 1120 urothelial carcinoma patients undergoing radical cystectomy and urinary diversion, including 411/1120 patients (37%) who received a continuous intra-operative administration of more than 2 μg kg BW h norepinephrine. MAIN OUTCOME MEASURES:The primary outcome was time to tumour recurrence within 5 years after surgery, with death as competing outcome. We used inverse probability of treatment weighting to adjust for imbalances between treatment groups, one having received more than 2 μg kg BW h norepinephrine and the other having received less. We furthermore adjusted for intra-operative variables or years of surgery as sensitivity analyses. RESULTS:The continuous administration of more than 2 μg kg BW h norepinephrine slightly increased tumour recurrence (hazard ratio: 1.47, 95% CI 0.98 to 2.21; P = 0.061). After adjustment for intra-operative variables, and year of surgery hazard ratios were 1.82 (95% CI 1.13 to 2.91, P = 0.013) and 1.85 (95% CI 1.12 to 3.07, P = 0.017), respectively. Overall mortality (with or without tumour recurrence) was not affected by norepinephrine (hazard ratio: 0.84, 95% CI 0.65 to 1.08, P = 0.170). CONCLUSION:Continuous administration of more than 2 μg kg BW h norepinephrine was associated with a slightly increased hazard ratio for tumour recurrence if adjusted for intra-operative variables and year of surgery. This observation could reflect a low potential pro-oncogenic effect of norepinephrine during the intra-operative period. TRIAL REGISTRATION:Not applicable.
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最新影响因子:4.183 | 期刊ISSN:0265-0215 | CiteScore:1.95 |
出版周期:Monthly | 是否OA:YES | 出版年份:1984 |
期刊官方网址:http://journals.cambridge.org/action/displayJournal?jid=EJA
自引率:16.80% | 研究方向:医学-麻醉学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published on behalf of the European Academy of Anaesthesiology. The European Journal of Anaesthesiology publishes original work of high scientific quality. Preference is given to experimental work or clinical observation in man, and to laboratory work of clinical relevance. The Journal also publishes commissioned reviews by an authority in a field of interest to those working in anaesthesiology or intensive care. Abstracts of Academy meetings, editorials, book reviews, news and notices are also included.
欧洲麻醉学学会出版代表。《欧洲麻醉学杂志》出版了高科学质量的原著。对人的实验工作或临床观察以及与临床相关的实验室工作给予优先考虑。《华尔街日报》还发布了一份权威机构委托的对从事麻醉或重症监护工作的人感兴趣领域的评论。学术会议、社论、书评、新闻和通知的摘要也包括在内。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ANESTHESIOLOGY (麻醉学) 2区 |
6/31 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
74 | 68 | 6 |
引文计数(2018)
文献(2015-2017)
1046次引用
537篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Anesthesiology and Pain Medicine
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研究方向:麻醉
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影响因子:2.566
ISSN:0739-7240
研究方向:农林科学-奶制品与动物科学
影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
影响因子:1.297
ISSN:0028-2804
研究方向:医学-精神病学
影响因子:4.604
ISSN:1092-8529
研究方向:医学-精神病学
影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
ISSN:0269-8811
研究方向:医学-精神病学
影响因子:6.533
ISSN:0165-0327
研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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