发表一篇学和医学成像类SCI论文
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Abstract:
:Alzheimer's disease (AD), the most common cause of dementia, leads to neuronal damage and deterioration of cognitive functions in aging brains. There is evidence suggesting the participation of noncoding RNAs in AD-associated pathophysiology. A potential linkage between AD and lncRNA-associated competing endogenous RNA (ceRNA) networks has been revealed. Nevertheless, there are still no genome-wide studies which have identified the lncRNA-associated ceRNA pairs involved in AD. For this reason, deep RNA-sequencing was performed to systematically investigate lncRNA-associated ceRNA mechanisms in AD model mice (APP/PS1) brains. Our results identified 487, 89, and 3,025 significantly dysregulated lncRNAs, miRNAs, and mRNAs, respectively, and the most comprehensive lncRNA-associated ceRNA networks to date are constructed in the APP/PS1 brain. GO analysis revealed the involvement of the identified networks in regulating AD development from distinct origins, such as synapses and dendrites. Following rigorous selection, the lncRNA-associated ceRNA networks in this AD mouse model were found to be mainly involved in synaptic plasticity as well as memory (Akap5) and regulation of amyloid-β (Aβ)-induced neuroinflammation (Klf4). This study presents the first systematic dissection of lncRNA-associated ceRNA profiles in the APP/PS1 mouse brain. The identified lncRNA-associated ceRNA networks could provide insights that facilitate AD diagnosis and future treatment strategies.
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最新影响因子:5.955 | 期刊ISSN:1945-4589 | CiteScore: |
出版周期:Monthly | 是否OA:YES | 出版年份:2008 |
期刊官方网址:http://www.aging-us.com/
期刊投稿地址:http://aging.msubmit.net/
自引率:7.40% | 研究方向:CELL BIOLOGY- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Aging-US
老龄化
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CELL BIOLOGY (细胞生物学) 2区 GERIATRICS & GERONTOLOGY (老年医学) 2区 |
48/190 5/53 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
149 | 146 | 3 |
引文计数(2018)
文献(2015-2017)
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发表一篇学和医学成像类SCI论文
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