发表一篇学和医学成像类SCI论文
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Abstract:
:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related mortality, and patients with HCC show poor response to currently available treatments, which demands new therapies. We recently developed a synthetic microRNA-based molecularly targeted therapy for improving HCC response to chemotherapy by eliminating drug resistance. We used ultrasound-targeted microbubble destruction (UTMD) to locally deliver microRNA-loaded nanoparticles to HCC. Since the immune microenvironment plays a crucial role in HCC disease development and response to treatment, and UTMD and microRNAs have the potential to interfere with the immune system, in this study we analyzed the immunomodulatory effects of UTMD and miRNAs in HCC. We used an immunocompetent syngeneic HCC mouse model for the study. We conducted cytokine profiling in tumor, lymph nodes, and serum of animals within the first 24 h of treatment to analyze changes in the level of pro- and antitumoral cytokines. The results showed: (1) Hepa1-6 syngeneic tumors expressed HCC-related cytokines, (2) UTMD-microRNA combination therapy triggered transient cytokine storms, and (3) delivery of microRNA-122 and anti-microRNA-21 affected the immune microenvironment by decreasing the level of GM-CSF in tumors while modulating protumoral IL-1α, IL-1β, IL-5, IL-6 and IL-17 and antitumoral IL-2 and IL-12 in tumor-proximal lymph nodes, and increasing IL-2 in the serum of tumor-bearing mice. Local delivery of targeted therapy by UTMD significantly reduced the concentration of IL-12 and IL-17 in lymph nodes of treated and contralateral tumors suggesting a systemic response. CONCLUSION: UTMD-mediated delivery of microRNA-122 and anti-microRNA-21 modulated the immune microenvironment of Hepa1-6 tumors at the level of cytokine expressions. Exploiting antitumoral immune effects could enhance the therapeutic efficacy of the proposed combination therapy for HCC.
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SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The journal publishes papers on the science and technology of the controlled release and delivery of drugs and other agents. The terms "controlled release" and "delivery" are used in their broadest sense to include mechanisms such as diffusion, chemical and enzymatic reactions, dissolution, osmosis, targeting, and the utilization and manipulation of biological processes. A broad spectrum of papers dealing with all aspects of controlled release and delivery, including gene delivery, tissue engineering and diagnostic agents, is encouraged. The use of prodrugs and carriers such as water-soluble polymers, micro- and nanoparticles, liposomes and micelles is included in the scope. Relevant papers on the toxicology and biocompatibility of drug delivery systems are also published. In addition to original full length papers, notes, reviews and rapid communications, the journal includes book reviews, reports of future meetings, and announcements pertaining to the activities of the Controlled Release Society.
该杂志发表了关于药物和其他制剂的控释和交付的科学和技术论文。术语“控制释放”和“传递”在广义上包括扩散、化学和酶反应、溶解、渗透、靶向以及生物过程的利用和操作等机制。鼓励发表涉及控释和释放所有方面的广泛论文,包括基因释放、组织工程和诊断试剂。前药和载体的使用,如水溶性聚合物,微和纳米颗粒,脂质体和胶束包括在范围内。还发表了有关药物给药系统毒理学和生物相容性的相关论文。除了原稿、笔记、评论和快速通讯外,该杂志还包括书评、关于未来会议的报告和有关管制发行协会活动的公告。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY (药学) 2区 CHEMISTRY, MULTIDISCIPLINARY (化学综合) 1区 |
23/171 9/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
479 | 394 | 85 |
引文计数(2018)
文献(2015-2017)
12605次引用
1596篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmaceutical Science
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#4/174
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影响因子:2.995
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研究方向:医学-核医学
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研究方向:医学-核医学
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研究方向:医学-核医学
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研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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