发表一篇学和医学成像类SCI论文
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Abstract:
INTRODUCTION AND OBJECTIVES:Hepatocellular carcinoma (HCC) can recur following radiofrequency ablation and other hyperthermic treatment modalities. Cancer stem cells (CSCs) are a subpopulation of HCC cells that are difficult to eradicate and largely responsible for tumor recurrences. Thus, the principal objective of this study was to determine whether human HCC CSCs are relatively thermal-resistant compared to non-stem or mature cancer cells (MCCs). MATERIALS AND METHODS:Epithelial cell adhesion molecule (EpCAM) positive enriched CSCs and EpCAM- MCCs were derived from a human HCC cell line using fluorescence activated cell sorting. Each cell population was exposed to 65°C heat for 0-16min and survival documented at various time points. RESULTS:Cell survival curves were similar in CSC and MCCs throughout the 16min heat exposure period. Maximum killing was obtained after 12-14min of heat exposure. Cytoprotective, heat shock proteins-70 (HSP70) and -90 (HSP90) mRNA expression were not disproportionately increased in CSCs. CONCLUSIONS:These results suggest that human HCC CSCs are not more thermal resistant than MCCs and therefore, do not support the hypothesis that HCC recurrences following hyperthermic treatment reflect CSC thermal-resistance.
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Published by Medigraphic. ISSN: 1665-2681. Official Journal of the Mexican Association of Hepatology.
由Medigraphic出版。ISSN: 1665 - 2681。 墨西哥肝病协会的官方杂志。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GASTROENTEROLOGY & HEPATOLOGY (胃肠肝病学) 4区 |
70/80 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
52 | 46 | 6 |
引文计数(2018)
文献(2015-2017)
530次引用
378篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hepatology
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#39/59
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影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
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影响因子:3.492
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研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
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研究方向:医学-精神病学
影响因子:6.533
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研究方向:医学-精神病学
影响因子:5.415
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影响因子:2.493
ISSN:0925-4927
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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