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Bioscience reports MicroRNA-221 是肥厚型梗阻性心肌病心肌肥厚和纤维化的潜在生物标志物。

影响因子：3.976 DOI：10.1042/BSR20191234

作者： Huang D,Chen Z,Wang J,Chen Y,Liu D,Lin K 发表时间：2020-02-04 01:01:30

from：《BIOSCIENCE REPORTS》

keywords： Huang DChen ZWang JChen YLiu DLin K

关键词：微小rna 肥厚型梗阻性心肌病心肌纤维化心肌肥厚

Abstract

AIM:Circulating microRNA expression has become a biomarker of cardiovascular disease; however, the association of microRNA expression between circulation and myocardium in hypertrophic cardiomyopathy remains unclear. The present study aimed to find a circulating biomarker correlated not only to myocardial expression, but also to cardiac hypertrophy and fibrosis. METHOD:Forty-two cases of hypertrophic obstructive cardiomyopathy (HOCM) diagnosed by echocardiography and magnetic resonance were analysed for microRNA expression in plasma and myocardial tissue. RESULTS:The results showed that myocardial miR-221 was significantly increased (z = -2.249, P = 0.024) and significantly correlated with collagen volume fraction (CVF) (r = 0.516, P < 0.001), late gadolinium enhancement (LGE) (r = 0.307, P = 0.048), and peripheral circulation (r = 0.434, P = 0.004). Moreover, circulating miR-221 expression was significantly correlated with CVF (r = 0.454, P = 0.002), LGE (r = 0.630, P = 0.004), maximum interventricular septal thickness (MIVST) of echocardiography (r = 0.318, P = 0.042), and MIVST of magnetic resonance (r = 0.342, P = 0.027). The area under the receiver operating characteristic curve of miR-221 was 0.764. CONCLUSIONS:Circulating miR-221 is consistent with that in myocardial tissue, and correlated with myocardial fibrosis and hypertrophy. It can be used as a biomarker for evaluating myocardial hypertrophy and fibrosis in HOCM.

摘要

目的: 循环 microRNA 表达已成为心血管疾病的生物标志物; 然而，肥厚型心肌病循环和心肌之间 microRNA 表达的相关性仍不清楚。本研究旨在寻找一种不仅与心肌表达相关，而且与心肌肥厚和纤维化相关的循环生物标志物。方法: 对 42 例超声心动图及磁共振诊断为肥厚型梗阻性心肌病 (HOCM) 的患者血浆及心肌组织中 microRNA 的表达进行分析。结果: 结果显示心肌 miR-221 显著升高 (z =-2.249，P = 0.024)，与胶原容积分数 (CVF) 显著相关 (r = 0.516, P

期刊介绍

《BIOSCIENCE REPORTS》 (点击进入期刊详情)

英文简介 : Bioscience Reports provides a home for sound scientific research in all areas of cell biology and molecular life sciences. Since 2012, Bioscience Reports has been fully Open Access and publishes all papers under the liberal CC BY licence, giving the life science community quality research to share and discuss. Bioscience Reports adheres to the Budapest Open Access Initiative (BOAI) definition of open access: that users have the right to read, download, copy, distribute, print, search, or link to the full texts of open access articles published in the Journal.

中文简介 : （来自Google、百度翻译）《生物科学报告》为细胞生物学和分子生命科学的所有领域提供了一个健全的科学研究基地。自2012年以来，《生物科学报告》已完全开放存取，并在自由学术委员会的授权下发表所有论文，让生命科学界共享和讨论高质量的研究。《生物科学报告》遵循布达佩斯开放获取倡议(BOAI)对开放获取的定义:用户有权阅读、下载、复制、分发、打印、搜索或链接到期刊上发表的开放获取文章的全文。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
生物	BIOCHEMISTRY & MOLECULAR BIOLOGY (生化与分子生物学) CELL BIOLOGY (细胞生物学)	149/293 116/190

大类(学科)

小类(学科)

学科排名

生物

BIOCHEMISTRY & MOLECULAR BIOLOGY (生化与分子生物学)

CELL BIOLOGY (细胞生物学)

149/293
116/190

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
251	225	26

总被引频次 :3757

特征因子 : 0.007210

影响因子趋势图

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