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Archives of disease in childhood. Fetal and neonatal edition 极早产儿缺氧和脑室内出血的负担。

影响因子：6.643 DOI：10.1136/archdischild-2019-316883

作者： Ng IHX,da Costa CS,Zeiler FA,Wong FY,Smielewski P,Czosnyka M,Austin T 发表时间：2020-07-10 14:30:39

from：《Archives of Disease in Childhood-Fetal and Neonatal Edition》

keywords： Ng IHXda Costa CSZeiler FAWong FYSmielewski PCzosnyka MAustin T

关键词：成像监控新生儿学神经发育神经残疾

Abstract

OBJECTIVE:Thresholds of cerebral hypoxia through monitoring of near-infrared spectroscopy tissue oxygenation index (TOI) were used to investigate the relationship between intraventricular haemorrhage (IVH) and indices of hypoxia. DESIGN:Prospective observational study. SETTING:A single-centre neonatal intensive care unit. PATIENTS:Infants <28 weeks' gestation with an umbilical artery catheter. METHODS:Thresholds of hypoxia were determined from mean values of TOI using sequential Χ2 tests and used alongside thresholds from existing literature to calculate percentage of time in hypoxia and burden of hypoxia below each threshold. These indices were then compared between IVH groups. RESULTS:44 infants were studied for a median of 18.5 (range 6-21) hours in the first 24 hours of life. Sequential Χ2 analysis yielded a TOI threshold of 71% to differentiate between IVH (16 infants) and no IVH (28 infants). Percentage of time in hypoxia was significantly higher in infants with IVH than those without, using thresholds of 60%-67%. Burden of hypoxia was significantly higher in infants with IVH than without, using thresholds of 62%-80%. With the threshold of 71%, percentage of time in hypoxia was lower by 12.2% with a 95% CI of (-25.7 to 1.2) (p=0.073), and the burden of hypoxia was lower by 29.2% hour (%h) (95% CI -55.2 to -3.1)%h (p=0.012) in infants without IVH than those with IVH. CONCLUSIONS:Using defined TOI thresholds, infants with IVH spent higher percentage of time in hypoxia with higher burden of cerebral hypoxia than those without, in the first 24 hours of life.

摘要

目的: 通过近红外光谱组织氧合指数 (TOI) 监测脑缺氧阈值，探讨脑室出血 (IVH) 与缺氧指标的关系。设计: 前瞻性观察性研究。单位: 单中心新生儿重症监护病房。患者: 妊娠 <28 周的婴儿使用脐动脉导管。方法: 使用序贯 Χ2 试验从TOI的平均值确定缺氧阈值，并与现有文献的阈值一起使用，计算缺氧时间百分比和缺氧负荷低于每个阈值。然后比较IVH组之间的这些指标。结果: 44 名婴儿在出生后 24 小时内的中位数为 18.5 (范围 6-21) 小时。序贯 χ 2 分析得出的TOI阈值为 71%，以区分IVH (16 例婴儿) 和无IVH (28 例婴儿)。IVH婴儿缺氧时间百分比显著高于无IVH婴儿，阈值为 60%-67%。IVH婴儿的缺氧负担显著高于无IVH婴儿，阈值为 62%-80%。阈值为 71% 时，缺氧时间百分比降低 12.2%，95% CI为 (-25.7 ~ 1.2) (p = 0.073)，无IVH的婴儿缺氧负担比无IVH的婴儿低 29.2% 小时 (% h) (95% ci-55.2 ~-3.1)% h (p = 0.012)。结论: 使用定义的TOI阈值，在生命的最初 24 小时内，IVH婴儿在缺氧和脑缺氧负担较高的时间百分比高于无IVH婴儿。

期刊介绍

《Archives of Disease in Childhood-Fetal and Neonatal Edition》 (点击进入期刊详情)

英文简介 : The Fetal and Neonatal Edition of the Archives of Disease in Childhood is published bimonthly with the aim of ensuring that perinatal-neonatal paediatrics maintains its strong academic research base and to bring together in one journal quality research and reviews in this field. Original research papers focus on fetal and neonatal physiology and clinical practice, genetics, perinatal epidemiology and neurodevelopmental outcomes. The scientific quality of published material is very high and the review articles are subject to the same expert peer review as the original papers.

中文简介 : （来自Google、百度翻译）《儿童疾病档案》的胎儿和新生儿版每月出版两期，目的是确保围产儿-新生儿儿科保持其强大的学术研究基础，并将该领域的优质研究和评论汇集在一份期刊上。最初的研究论文集中在胎儿和新生儿的生理和临床实践，遗传学，围产期流行病学和神经发育结果。发表的论文具有很高的科学质量，所发表的评论文章必须经过与原论文相同的专家同行评审。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	PEDIATRICS (儿科)	7/124

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
89	75	14

总被引频次 :4193

特征因子 : 0.008410

影响因子趋势图

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