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The Journal of dermatological treatment 奥马珠单抗单药或联合治疗慢性自发性荨麻疹的有效性和安全性的真实数据: 一项回顾性队列研究。

影响因子：3.23 DOI：10.1080/09546634.2019.1589639

作者： Salman A,Ergun T,Gimenez-Arnau AM 发表时间：2020-07-11 01:06:33

from：《JOURNAL OF DERMATOLOGICAL TREATMENT》

keywords： Salman AErgun TGimenez-Arnau AM

关键词：慢性自发性荨麻疹慢性荨麻疹奥马珠单抗真实生活

Abstract

:Background: The real-life data on the effectiveness and safety of omalizumab in chronic spontaneous urticaria (CSU) with validated methods are scarce. There is also a lack of information on the use of combination treatments.Methods: A retrospective cohort study was done to evaluate the effectiveness and safety of omalizumab in real-life conditions. The patients with CSU treated with omalizumab between 2015 and 2018 were included. The response to therapy was evaluated using urticaria activity score over 7 days (UAS7) and urticaria control test (UCT).Results: A total of 106 patients were included. A complete response (CR) (UAS7:0) and a well-controlled activity (WCA) (UAS7:1 to <6) were observed in 50 (47.2%) and 35 (33%) patients, respectively. The number of patients with an UCT score ≥12 was also significantly increased. Higher rates of CR/WCA were observed with omalizumab monotherapy compared to combination with antihistamines. The combination of dapsone, colchicine, and omalizumab provided additional benefit in a small group.Conclusion: Treatment with omalizumab provided a rapid and sustainable improvement in real-life settings. The use of omalizumab as monotherapy or combined with antihistamines does not show differences in the treatment response. The combination of omalizumab with immunomodulatory agents might be of benefit in selected cases.

摘要

背景: 奥马珠单抗治疗慢性自发性荨麻疹 (CSU) 的有效性和安全性的真实数据很少。方法: 一项回顾性队列研究评估了奥马珠单抗在现实生活条件下的有效性和安全性。纳入 2015 年至 2018 年期间接受奥马珠单抗治疗的CSU患者。采用荨麻疹活动度评分超过 7 天 (UAS7) 和荨麻疹对照test (UCT) 评价治疗效果。结果: 共纳入 106 例患者。在 5 0 (47.2%) 中观察到完全反应 (CR) (UAS7:0) 和控制良好的活性 (WCA) (UAS7:1 至 <6) 和 35 (33%) 患者，分别。UCT评分 ≥ 12 分的患者数量也显著增加。与联合抗组胺药相比，奥马珠单抗单药治疗观察到更高的CR/WCA率。氨苯砜、秋水仙碱和奥马珠单抗联合用药在一个小组中提供了额外的益处。结论: 奥马珠单抗治疗在现实生活中提供了快速和可持续的改善。使用奥马珠单抗作为单药治疗或与抗组胺药联合使用并没有显示治疗反应的差异。奥马珠单抗与免疫调节剂联合使用可能对选定病例有益。

期刊介绍

《JOURNAL OF DERMATOLOGICAL TREATMENT》 (点击进入期刊详情)

英文简介 : Journal of Dermatological Treatment covers all aspects of the treatment of skin disease, including the use of topically and systemically administered drugs and other forms of therapy. With its focus on treatment and full-colour illustrations, the journal is of immense practical value to the clinical dermatologist and all those concerned with improving the management of skin disease.

中文简介 : （来自Google、百度翻译）《皮肤治疗杂志》涵盖了皮肤疾病治疗的所有方面，包括局部和系统用药以及其他治疗形式。以治疗和全彩插图为重点，该杂志具有巨大的实用价值的临床皮肤科医生和所有有关改善皮肤疾病的管理。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	DERMATOLOGY (皮肤病学)	25/64

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
123	98	25

总被引频次 :2063

特征因子 : 0.003350

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