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Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 预后营养指数是一线化疗治疗的转移性非小细胞肺癌患者的预后和预测因素吗？

影响因子：3.359 DOI：10.1007/s00520-019-05055-x

作者： Bozkaya Y,Köstek O,Sakin A,Özyükseler DT,Şakalar T,Çil İ 发表时间：2020-07-10 20:00:40

from：《SUPPORTIVE CARE IN CANCER》

keywords： Bozkaya YKöstek OSakin AÖzyükseler DTŞakalar TÇil İ

关键词：一线化疗转移非小细胞肺癌小野寺预后营养指数预后

Abstract

PURPOSE:We aimed to assess the prognostic and predictive significance of pretreatment Onodera's prognostic nutritional index (OPNI) in metastatic non-small cell lung cancer patients (NSCLC) treated with first-line chemotherapy. MATERIALS AND METHODS:Patients with metastatic NSCLC who attended five different medical oncology clinics between December 2008 and January 2018 were retrospectively analyzed. The optimal cut-off point for OPNI was performed by a receiver operating characteristic (ROC) curve analysis. Patients were assigned to either the low OPNI group or high OPNI group. RESULTS:A total of 333 patients were included in the study. Significant differences between the low and high OPNI groups were found regarding the rates of response to chemotherapy, sex, and hemoglobin level (p < 0.05). The patients in high OPNI group had a longer overall survival (OS) (15.3 vs. 10.6 months, p < 0.001) and progression-free survival (PFS) (6.7 vs. 5.3 months, p < 0.001) compared to the patients in low OPNI group. A multivariate analysis using Cox regression model revealed that a high OPNI score was an independent prognostic factor of OS (HR = 1.535, p = 0.002) and PFS (HR = 1.336, p = 0.014), but failed to demonstrate a statistical significance of pretreatment OPNI scores in predicting treatment response (p = 0.56). CONCLUSIONS:Pretreatment OPNI is an independent prognostic factor for OS and PFS in metastatic NSCLC patients treated with first-line chemotherapy. Thus, it may be used as easily calculated and low-cost prognostic tool in the routine clinical practice in this patient group.

摘要

目的: 我们的目的是评估预处理小野寺预后营养指数 (OPNI) 对一线化疗治疗的转移性非小细胞肺癌 (NSCLC) 患者的预后和预测意义。材料和方法: 回顾性分析 2008 年 12 月至 2018 年 1 月在 5 个不同肿瘤内科门诊就诊的转移性NSCLC患者。通过受试者工作特征 (ROC) 曲线分析进行OPNI的最佳截点。患者被分配到低OPNI组或高OPNI组。结果: 共有 333 例患者纳入研究。低和高OPNI组在化疗缓解率、性别和血红蛋白水平方面存在显著差异 (p <0.05)。高OPNI组患者总生存期 (OS) 较长 (15.3 vs. 10.6 个月，p <0.001) 和无进展生存期 (PFS) (6.7 vs. 5.3 个月，p <0.001) 与低OPNI组患者相比。Cox回归模型多因素分析显示，高OPNI评分是OS (hr = 1.535，p = 0.002) 和PFS (hr = 1.336，P = 0.014)，但未能证明治疗前OPNI评分预测治疗反应的统计学意义 (p = 0.56)。结论: 预处理OPNI是一线化疗的转移性NSCLC患者OS和PFS的独立预后因素。因此，在该患者组的常规临床实践中，它可以作为易于计算和低成本的预后工具使用。

期刊介绍

《SUPPORTIVE CARE IN CANCER》 (点击进入期刊详情)

英文简介 : Supportive Care in Cancer aims to provide members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It will cover primarily medical technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing rehabilitative psychosocial and spiritual issues of support will also be included. Papers focusing on aspects of specific antineoplastic treatments will not normally be accepted.

中文简介 : （来自Google、百度翻译）癌症支持护理旨在向跨国癌症支持护理协会（MACC）成员和所有其他感兴趣的个人团体和机构提供癌症患者支持护理各方面的最新科学和社会信息。它将主要涵盖关于支持治疗和护理的医学技术和外科主题，这些支持治疗和护理可以在疾病的所有阶段补充或替代基本的癌症治疗。护理康复的心理社会和精神支持问题也将包括在内。通常不接受专门针对特定抗肿瘤治疗方面的论文。

CIRCULATION RESEARCH 期刊中科院评价数据

新中科院分区

大类(学科)	小类(学科)	学科排名
医学	REHABILITATION (康复医学) HEALTH CARE SCIENCES & SERVICES (卫生保健与服务) ONCOLOGY (肿瘤学)	23/94 136/223 12/65

大类(学科)

小类(学科)

学科排名

医学

REHABILITATION (康复医学)

HEALTH CARE SCIENCES & SERVICES (卫生保健与服务)

ONCOLOGY (肿瘤学)

23/94
136/223
12/65

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
403	362	41

总被引频次 :11975

特征因子 : 0.024130

影响因子趋势图

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