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Physiological reviews HIV相关肺病的发病机制: 免疫、感染和炎症。

影响因子：46.5 DOI：10.1152/physrev.00039.2018

作者： Cribbs SK,Crothers K,Morris A 发表时间：2020-07-10 20:00:40

from：《PHYSIOLOGICAL REVIEWS》

keywords： Cribbs SKCrothers KMorris A

关键词：艾滋病毒免疫感染炎症肺

Abstract

:Despite anti-retroviral therapy (ART), human immunodeficiency virus-1 (HIV)-related pulmonary disease continues to be a major cause of morbidity and mortality for people living with HIV (PLWH). The spectrum of lung diseases has changed from acute opportunistic infections resulting in death to chronic lung diseases for those with access to ART. Chronic immune activation and suppression can result in impairment of innate immunity and progressive loss of T cell and B cell functionality with aberrant cytokine and chemokine responses systemically as well as in the lung. HIV can be detected in the lungs of PLWH and has profound effects on cellular immune functions. In addition, HIV-related lung injury and disease can occur secondary to a number of mechanisms including altered pulmonary and systemic inflammatory pathways, viral persistence in the lung, oxidative stress with additive effects of smoke exposure, microbial translocation, and alterations in the lung and gut microbiome. Although ART has had profound effects on systemic viral suppression in HIV, the impact of ART on lung immunology still needs to be fully elucidated. Understanding of the mechanisms by which HIV-related lung diseases continue to occur is critical to the development of new preventive and therapeutic strategies to improve lung health in PLWH.

摘要

: 尽管抗逆转录病毒治疗 (ART)，人类免疫缺陷病毒-1 (HIV) 相关的肺部疾病仍然是艾滋病毒感染者 (PLWH) 发病和死亡的主要原因。对于那些获得ART的人来说，肺部疾病谱已经从导致死亡的急性机会性感染转变为慢性肺部疾病。慢性免疫激活和抑制可导致先天免疫受损，T细胞和b细胞功能进行性丧失，全身和肺部细胞因子和趋化因子反应异常。HIV可在PLWH的肺部被检测到，并对细胞免疫功能产生深远影响。此外，HIV相关的肺损伤和疾病可能继发于许多机制，包括改变肺部和全身炎症通路，病毒在肺部持续存在，氧化应激与烟雾暴露的累加效应，微生物移位，以及肺和肠道微生物组的改变。虽然ART对HIV的全身病毒抑制有深远的影响，但ART对肺免疫学的影响仍有待充分阐明。了解HIV相关肺部疾病继续发生的机制对于开发新的预防和治疗策略以改善PLWH的肺部健康至关重要。

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《PHYSIOLOGICAL REVIEWS》 (点击进入期刊详情)

英文简介 : Presents review articles relating to current developments in all areas of physiological research.

中文简介 : （来自Google、百度翻译）介绍与生理研究所有领域的当前发展相关的评论文章。

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新中科院分区

大类(学科)	小类(学科)	学科排名
医学	PHYSIOLOGY (生理学)	1/83

新发布的期刊年发文量

年度总发文量	年度论文发表量	年度综述发表量
36	0	36

总被引频次 :28672

特征因子 : 0.026830

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