- 论文标题 期刊级别 审稿状态
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Features Associated with Recurrence of Idiopathic Orbital Inflammatory Pseudotumor
Purpose: To explore factors which lead to recurrence of idiopathic orbital inflammatory pseudotumor (IOIP).Methods: Idiopathic orbital inflammatory pseudotumor in 209 cases between Jan 1,1978 and Dec 31, 1999 in our hospital was evaluated retrospectively. The comparison of clinical and pathological parameters between patients with at least one episode of recurrence and those with no recurrence at all was performed and analyzed using logistic regression method.Results: Follow-up results (with a mean follow-up time of 3.4 years, ranging from 0.5 year to 21.0 years) showed that the recurrence rate of IOIP was 41%. Sex and proptosis were associated with the recurrence of IOIP. Male gender was more likely to relapse than female counterparts, with the male being 52% and female being 25%.The severer the proptosis is, the higher the rate of recurrence. Among the clinical subtypes of IOIP, the rate of recurrence (17%) in cases with dacryoadinitis was the lowest, followed by anterior local orbital mass (44%), posterior orbital mass (54%),myositis (75%) and diffuse subtype (100%). However, the clinical subtypes did not show significant relationship with the recurrence of IOIP.Conclusions: Male gender and severe proptosis are associated with a higher recurrent rate in patients with IOIP.
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硅油填充术在不伴有视网膜脱离外伤性感染性眼内炎的临床应用
目的:观察玻璃体切除联合眼内注药或硅油填充术对眼球穿通伤后合并感染性眼内炎不伴视网膜脱离的疗效.方法:应用经睫状体平坦部玻璃体切除术,以联合眼内注药或硅油填充术分组治疗30只眼球穿通伤并发感染性眼内炎不伴有视网膜脱离患者,术后予以静脉、结膜下及眼药水途径给予抗感染抗炎治疗.结果:玻璃体切除术后追踪随访3～12个月,2组30只眼细菌性感染全部控制,术后视力较术前视力有显著性提高,联合眼内注药组19只眼,其中4只眼(21.1%)发生视网膜脱离;联合硅油填充组11只眼,其中术后1只眼(9%)发生视网膜脱离.两组术后并发症发生率均无明显差异(P＞0.05).结论:玻璃体切除联合硅油填充术能有效控制炎症,稳定视网膜功能,对一些视网膜情况不佳或炎症难以控制的患者可以考虑术中应用硅油.
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视乳头结构即时测量新法——+78D前置镜合并目镜刻度尺法
目的:探讨+78D前置镜合并目镜刻度尺测量法作为新的视乳头结构即时测量方法的测量一致性,并和直接眼底镜进行测量一致性比较.方法:两名检查者分别使用直接检眼镜和+78D前置镜合并目镜刻度尺法对所有受检眼(477眼)测量视神经垂直杯盘比比值,计算仪器间的测量可重复性.对前100只眼,两名测量者均采用+78D前置镜合并目镜刻度尺法测量垂直杯盘比、视盘直径和视杯直径,均采用直接检眼镜测量垂直杯盘比,计算同一测量仪器的检查者间可重复性.结果:本研究受检者有257名(477眼).两名检查者利用+78D前置镜合并目镜刻度尺法测量视盘直径、视杯直径和垂直杯盘比得出95%一致性区间分别为-4.3～+4.5、-7.2～+6.2和-2.2～+2.8,没有成比例偏倚,而直接检眼镜的95%一致性区间为-0.33～+0.38.两种测量方法进行比较发现直接眼底镜倾向于高估垂直杯盘比值,没有成比例偏倚.结论:+78D前置镜合并目镜刻度尺测量垂直杯盘比的检查者间一致性测量结果较好,测量值变异比直接检眼镜小,并且直接眼底镜倾向于高估垂直杯盘比值.建议+78D前置镜合并目镜刻度尺用于临床检查即时判断以及基层和社区青光眼筛查.
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非球面人工晶状体植入术后早期视功能的临床研究
目的:初步评估非球面人工晶状体植入术后早期视功能情况.方法:将88例(91只眼)白内障患者随机分为AcrySof(R)IQ(SN60WF)、KS-3Ai和AcrySof Natural(SN60AT)人工晶状体组.观察患者术后1 d、1周和1月佳矫正视力和术后1月对比敏感度及主观视觉等视功能情况.结果:术后第1天KS-3Ai组佳矫正视力明显优于其余两组(P＜0.05),术后1周、1月三组佳矫正视力差异均无显著性意义(P＞0.05).AcrySof(R)IQ和KS-3Ai组中、低频区对比敏感度在瞳孔直径2.5 mm～4.0 mm及5.0 mm～6.0 mm时均优于AcrySof Natural组(P＜0.05),而AcrySof(R)IQ和KS-3Ai两组比较无显著性意义(P＞0.05).采用VF/QOL问卷调查显示AcrySof(R)IQ和KS-3Ai组患者的总体满意度好.结论:非球面人工晶状体能明显提高白内障患者术后对比敏感度,改善患者术后视觉质量.
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25G经结膜无缝合巩膜切口与常规20G巩膜切口愈合的实验研究
目的:观察比较25G经结膜无缝合巩膜切口与常规20G巩膜切口的愈合情况.方法:版纳实验用小型猪4只,采用随机对照的方法,选择一只眼行25G巩膜切开术(25G组),另一眼行常规20G玻璃体手术(20G组).术后0 d、10 d、20 d、60 d分别观察大体和石腊切片苏木素-伊红(HE)染色,比较两组巩膜切口的愈合情况.结果:25G组的巩膜切口明显小于20G组.术后第1天,20G组结膜充血较25G组明显.25G组的巩膜切口术后10 d已基本愈合,仅有少量炎症细胞.20G组的巩膜切口在术后20 d仍未完全愈合,有大量的炎症细胞浸润.术后60 d两组切口均无炎症细胞浸润.术后,25G组中1个切口,20G组中2个切口可见玻璃体嵌顿;25G组中2个切口,20G组中4个切口可见纤维组织内生.结论:与20G手术相比,25G手术巩膜切口具有创伤小、愈合快、炎症反应轻的优点.
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翼状胬肉中血管增殖与Cox-2、VEGF表达及其临床意义
目的:探讨Cox-2、VEGF在翼状胬肉发生发展中的作用.方法:应用免疫组化Elivision法检测30例翼状胬肉、15例正常结膜中Cox-2、VEGF的表达.结果:30例翼状胬肉和15例正常结膜中VEGF的阳性表达率,静止期为57.1%,进行期为69.2%,复发性翼状胬肉为100.0%,正常结膜为13.3%;Cox-2的阳性表达率,静止期为42.8%,进行期为84.6%,复发性翼状胬肉为90.0%,正常结膜为6.6%.Cox-2、VEGF阳性表达在翼状胬肉与正常结膜两组间差异有显著意义,P＜0.05和P＜0.001.结论:Cox-2、VEGF在翼状胬肉中的高表达,提示有新生血管化的发生,可能与翼状胬肉的发生、发展和术后复发有关,选择性Cox-2、VEGF抑制剂可望成为治疗翼状胬肉新的靶点.
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In Vitro Study on Lethal Effect of Human Choroidal Melanoma OCM-1 Cell Line by Repeating-70℃Freeze Thawing
Objective: To investigate the effects of repeating -70℃ freeze thawing on human choroidal melanoma cell line OCM-1.Methods: OCM-1 cells were frozen by repeating -70℃ freeze thawing with various durations and frequencies. Then the inhibit rate of cells was examined by MTT essay.The cell viability was measured by monoclonal formation assay. We also used the HE staining, immunohistochemistry staining and the laser-scanning confocal microscopy (LSCM) to investigate the morphological changes of the cells.Results: The growth of OCM-1 cells was inhibited by repeating -70℃ freeze thawing in time-dependent and frequency-dependent manners (P ＜ 0.01). Different morphous including necrosis and apoptosis of the cells could be observed after -70℃ freeze thawing by the LSCM.Conclusion: Repeating -70℃ freeze thawing can not only kill cells directly and induce considerable cells to apoptosis, but also inhibit the growth of the survivals. The kill and wound ratio of the cells disposal with different times and frequencies present variance. And the distinction when treated with different frequencies during the same time is much more significant than different times with the same frequency, which guide clinical workers to choose repeating cryotherapy with short term method instead of single cryotherapy with long term in choroidal melanoma treatment.
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益气明目口服液对光损伤模型大鼠的疗效观察
目的:探讨中药益气明目口服液对实验性视网膜光损伤模型大鼠的治疗作用.方法:Sprague-Dawley大鼠54只随机分为阴性对照组、光损伤模型组、益气明目口服液组.采用绿色荧光灯(Lux为1900±106.9)24 h持续光照射建立大鼠视网膜急性光损伤模型,光照前分别采用等量蒸馏水和益气明目口服液灌胃治疗7 d.光照后6 d,观察视网膜电图的改变,检测视网膜组织中超氧化物歧化酶(SOD)的活性及丙二醛(MDA)的含量,并进行视网膜透视电子显微镜和光学显微镜的组织学观察.结果:光损伤后6 d,益气明目口服液对实验大鼠视网膜光损伤后ERG a波及b波振幅的降低均有保护作用,益气明目口服液组视网膜中SOD的活性高于光损伤模型组(P＜0.01),而MDA的含量则低于光损伤模型组(P＜0.01);通过视网膜透视电子显微镜和光学显微镜的组织学观察,益气明目口服液组的病理组织学损害较光损伤模型组明显减轻.结论:益气明目口服液是一种治疗视网膜光损害性疾病的有效中药复方制剂.
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非球面人工晶状体的研究进展
非球面人工晶状体是目前临床上备受关注的一种新型人工晶状体,它具有减轻像差和提高白内障患者术后视觉质量等优点,较传统的球面人工晶状体更能满足人们对高质量视力的要求,因而近年来非球面人工晶状体不断涌现,有望成为未来人工晶状体的主导.本文将从非球面人工晶状体的设计特点、原理、分类、临床应用以及功能评价指标等方面作一综述.
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临床视觉电生理标准化进展
为满足临床视觉电生理检查规范化需要,国际临床视觉电生理学会近十余年来陆续颁布了系列标准化方案,目前国内实验室规范化状况有很大改进,但距新方案的要求还有差距.本文综述了新方案的主要内容,以便国内实验室提高改进.
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硫醇转移酶和硫氧还蛋白系统在白内障中的研究
晶状体透明性的维持需要平衡的氧化还原状态和恰当的巯基/二硫化物比例,其丰富的谷胱甘肽和内在修复酶系统作为重要的防御屏障对于维持晶状体功能非常重要,然而,在老化白内障晶状体中,谷胱甘肽含量显著下降.近年对硫醇转移酶和硫氧还蛋白系统的研究发现:硫醇转移酶特异地使蛋白质与谷胱甘肽形成的二硫化物脱硫醇,恢复蛋白质的自由巯基,维持蛋白质或酶的功能;硫氧还蛋白系统能使蛋白质二硫化物脱硫醇,是细胞内氧化还原稳态的重要调节子.两者协同作用能有效地修复晶状体蛋白质和酶的巯基,维持晶状体的功能.
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| 2018 | 01 02 03 04 |
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